The Thyroid Cure Research References

The Thyroid Cure research references:

The functional mind/body approach introduced in The Thyroid Cure is backed up by the latest research in functional medicine, immunology, psychoneuroimmunology, epigenetics, nutrigenomics, toxicology and environmental studies.

We have included the endnotes online for easy reference.

Introductory Section

  1. Amino N. Autoimmunity and hypothyroidism. Baillieres Clin Endocrinol Metab. 1988 Aug;2(3):591-617. http://www.ncbi.nlm.nih.gov/pubmed/3066320

  2. Lipton B, Bhaerman S. Spontaneous Evolution Our Positive Future and a Way to Get There From Here. 3rd Edition. Hay House; 2010

  3. American Autoimmune Related Diseases Association. Questions and Answers. http://www.aarda.org/autoimmune-information/questions-and-answers/

  4. American Association of Clinical Endocrinologists. Hashimoto’s Thyroiditis. (2008) https://www.aace.com/files/hashimotos.pdf

  5. “cure.” Dictionary.com Unabridged. Random House, Inc. http://dictionary.reference.com/browse/cure

Part One

Chapter 1

  1. John Hopkins Medical. Autoimmune Disease Research. http://www.hopkinsmedicine.org/fox

  2. American Autoimmune Related Diseases Association. Questions and Answers. http://www.aarda.org/autoimmune-information/questions-and-answers/

Chapter 2

  1. Kornfeld R. The “New” Standard for Care in Medicine. Huffington Post. 12/2/2011 http://www.huffingtonpost.com/dr-robert-a-kornfeld/new-standard-medical-care_b_1117409.html

  2. IMS Institute for Healthcare Informatics, The Use of Medicines in the United States: Review of 2010, http://www.imshealth.com/deployedfiles/imshealth/Global/Content/IMS%20Institute/Static%20File/IHII_UseOfMed_report.pdf

  3. Centers for Medicare and Medicaid Services. National Health Expenditures 2011 Highlights. http://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/NationalHealthExpendData/downloads/highlights.pdf,

  4. Herper M. The Best Selling Drugs in America. Forbes. 4/19/2011 http://www.forbes.com/sites/matthewherper/2011/04/19/the-best-selling-drugs-in-america/2/

Chapter 3

  1. MacIntosh A. Understanding the Differences Between Conventional, Alternative, Complementary, Integrative and Natural Medicine. Townsend Letter, July 1999, http://tldp.com/medicine.htm

  2. MacIntosh A. Understanding the Differences Between Conventional, Alternative, Complementary, Integrative and Natural Medicine. Townsend Letter, July 1999, http://tldp.com/medicine.htm

  3. The National Center for Complementary and Alternative Medicine, NCCAM Facts-at-a-Glance and Mission, http://nccam.nih.gov/about/ataglance

  4. Avik S. A. Roy, Senior Fellow, Manhattan Institute for Policy Research, Stifling New Cures: The True Cost of Lengthy Clinical Drug Trials, Project FDA Report No. 5 April 2012  http://www.manhattan-institute.org/html/fda_05.htm#01

  5. MacIntosh A. Understanding the Differences Between Conventional, Alternative, Complementary, Integrative and Natural Medicine. Townsend Letter, July 1999, http://tldp.com/medicine.htm

Chapter 6

  1. Eggleton P. Stress protein–polypeptide complexes acting as autoimmune triggers. Clin Exp Immunol. 2003 October; 134(1): 6–8.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808840/

  2. Stojanovich L, Marisavljevich D. Stress as a trigger of autoimmune disease. Autoimmun Rev. 2008 Jan;7(3):209-13. http://www.sciencedirect.com/science/article/pii/B9780123739476000477

  3. Richardson B. DNA methylation and autoimmune disease. Clin Immunol. 2003 Oct;109(1):72-9. http://www.ncbi.nlm.nih.gov/pubmed/14585278

  4. Ercolini A M,  Miller S D. The role of infections in autoimmune disease. Clin Exp Immunol. 2009 January; 155(1): 1–15. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665673

  5. Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y. Infections and autoimmunity – friends or foes? Trends in Immunology – 1 August 2009 (Vol. 30, Issue 8, pp. 409-414) http://www.sciencedirect.com/science/article/pii/S1471490609001252

  6. Velavan TP, Ojurongbe O. Regulatory T cells and parasites. J Biomed Biotechnol. 2011;201(1):520940. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255565/

  7. Biagi F, Pezzimenti D, Campanella J, Corazza GR. Gluten exposure and risk of autoimmune disorders. Gut. 2002;51(1):140–141. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773261/

  8. Negro R.  Selenium and thyroid autoimmunity. Biologics. 2008 June; 2(2): 265–273. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721352/

  9. Bigazzi P E. Autoimmunity and Heavy Metals. Lupus December 1994 vol. 3 no. 6 449-453 http://lup.sagepub.com/content/3/6/449.abstract

  10. Orbach H, Agmon-Levin N, Zandman-Goddard G. Vaccines and autoimmune diseases of the adult. Discov Med. 2010 Feb;9(45):90-7. http://www.ncbi.nlm.nih.gov/pubmed/20193633

  11. Vial T, Descotes J. Autoimmune diseases and vaccinations. Eur J Dermatol. 2004 Mar-Apr;14(2):86-90. http://www.ncbi.nlm.nih.gov/pubmed/15196997

  12. Burek C L, Monica V. Talor M V. Environmental Triggers of Autoimmune Thyroiditis. J Autoimmun. 2009 Nov–Dec; 33(3-4): 183–189. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790188/

  13. Akis M, Verhagen J, Taylor A, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen specific T regulatory 1 and T helper 2 cells. J Exp Med 2004;199:1567-75

  14. Rook GA, Brunet LR. Old friends for breakfast. Clin Exp Allergy 2005;35:841-2

  15. Kidd P, Th1/Th2 Balance: The Hypothesis, its Limitations, and Implications for Health and Disease Alternative Medicine Review Vol. 8, Number 3  2003 (pp.223-246) http://www.altmedrev.com/publications/8/3/223.pdf

  16. Rappaport S M, Smith M T. Environment and Disease Risks. Science 22 October 2010: Vol. 330 no. 6003 pp. 460-461  http://www.sciencemag.org/content/330/6003/460.summary

Chapter 7

  1. Georgetown University Medical School. Thyroid Disease. http://medicine.georgetown.edu/divisions/endocrinology/knowledge/thyroid-disease

  2. Weetman A. Review Article: Graves’ Disease. N Engl J Med Online. Oct. 2000 http://isites.harvard.edu/fs/docs/icb.topic442065.files/Endocrine_Readings/Graves_Disease.pdf

  3. American Association of Clinical Endocrinologists. Hashimoto’s Thyroiditis. (2008) https://www.aace.com/files/hashimotos.pdf

Chapter 9

  1. Sword R, Zimbardo P, Hurry Sickness; Is Our Quest to Do All and Be All Costing Us Our Health?  Psychology Today Online Feb. 8, 2013 http://www.psychologytoday.com/blog/the-time-cure/201302/hurry-sickness

  2. The American Institute of Stress (AIS) http://www.stress.org

  3. Olpin N, Perceived Stress Levels and Sources of Stress Among College Students: Methods, Frequency, and Effectiveness of Managing Stress by College Students. Health Education PhD Dissertation. Southern Illinois University at Carbondale Mar. 29, 1996.  http://faculty.weber.edu/molpin/dissertation.htm

  4. Centers for Disease Control and Prevention. Crude and Age-Adjusted Percentage of Civilian, Non-institutionalized Population with Diagnosed Diabetes, United States, 1980–2011 http://www.cdc.gov/diabetes/statistics/prev/national/figage.htm

  5. Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Int J Clin Pract. 2010 Jul;64(8):1130-9 http://www.ncbi.nlm.nih.gov/pubmed/20642711

  6. Hyman M. Why Your Genes Don’t Determine Your Health. Huffington Post Online. 01/01/11 http://www.huffingtonpost.com/dr-mark-hyman/human-genome_b_803069.html

  7. Bronwell K.D. and Warner K.E. The Perils of Ignoring History: Big Tobacco Played Dirty and Millions Died. How Similar Is Big Food? The Milbank Quarterly, Vol. 87, No. 1, 2009 (pp. 259–294) http://www.yalerudds.org/resources/upload/docs/what/industry/Foodtobacco.pdf

  8. Nordlee J, Taylor S, Townsend J, Thomas L, Bush R,  Identification of A Brazil-Nut Allergen In Transgenic Soybeans. N Engl J Med 1996;334:688-92 http://genetica.ufcspa.edu.br/nutric/seminarios%20monitores/IDENTIFICATION_OF_A_BRAZIL-NUT_ALLERGEN_IN_TRANSGENIC_SOYBEANS%202008.pdf

  9. Aris A, Leblanc S. Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada. Reprod Toxicol. 2011;31(4):528–533. http://www.sciencedirect.com/science/article/pii/S0890623811000566

  10. Lin Z, Dongxia H, Xi C, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA Cell Research. 2011;22:107–126 http://www.nature.com/cr/journal/v22/n1/full/cr2011158a.html

  11. Miyake K, Tanaka T, McNeil PL Lectin-Based Food Poisoning: A New Mechanism of Protein Toxicity. PLoS ONE (2007) 2(8): e687. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000687

  12. Cordain L., Toohey L., Smith M.J., Hickey M.S. Modulation of immune function by dietary lectins in rheumatoid arthritis. Br. J. Nutr. 2000;83:207–217 http://www.ncbi.nlm.nih.gov/pubmed/10884708

  13. Jones L. Genetically modified foods. BMJ. 1999;318:581–584 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115027/?report=reader#B14

  14. Bishnoi S, Khetarpaul N, Yadav R. Effect of domestic processing and cooking methods on phytic acid and polyphenol contents of pea cultivars (Pisum sativum) Bishnoi S, Khetarpaul N, Yadav R. Effect of domestic processing and cooking methods on phytic acid and polyphenol contents of pea cultivars (Pisum sativum) Plant Foods for Human Nutrition June 1994, Volume 45, Issue 4, pp 381-388  http://link.springer.com/article/10.1007%2FBF01088088?LI=true#page-1

  15. Tracy B. How did genetically altered wheat end up in Oregon field? CBS News June 6, 2013 http://www.cbsnews.com/8301-18563_162-57588150/how-did-genetically-altered-wheat-end-up-in-oregon-field/

  16. Kasarda D, Can an Increase in Celiac Disease Be Attributed to an Increase in the Gluten Content of Wheat as a Consequence of Wheat Breeding? Journal of Agricultural and Food Chemistry 2013 61 (6), 1155-1159  http://pubs.acs.org/doi/full/10.1021/jf305122s#

  17. Davis W. Is gluten on the increase? Blog Online. Feb. 15, 2013 http://www.wheatbellyblog.com/2013/02/is-gluten-on-the-increase/

  18. Monetini L, Cavallo MG, Manfrini S, et al. Antibodies to bovine beta-casein in diabetes and other autoimmune diseases. Horm Metab Res. 2002 Aug;34(8):455-9 http://www.ncbi.nlm.nih.gov/pubmed/12198602

  19. US Dept. Of Agriculture. Genetically engineered varieties of corn, upland cotton, and soybeans, by State and for the Unites States, 2000-13. http://www.ers.usda.gov/data-products/adoption-of-genetically-engineered-crops-in-the-us.aspx#.Ua58DGTb1bs

  20. Bray G, Nielsen S, Popkin B. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004 79: 4 537-543 http://ajcn.nutrition.org/content/79/4/537.abstract

  21. Dufault R, LeBlanc B, Schnoll R, et al. Mercury from chlor-alkali plants: measured concentrations in food product sugar. Environmental Health. 2009;8:2. http://www.ncbi.nlm.nih.gov/pubmed/19171026

  22. Siegmund B, Leitner E, Pfannhauser W. Determination of the nicotine content of various edible nightshades (solanaceae) and their products and estimation of the associated dietary nicotine intake. J Agric Food Chem 1999;47:3113–20  http://www.ncbi.nlm.nih.gov/pubmed/10552617

  23. US Dept. Of Agriculture. Genetically engineered varieties of corn, upland cotton, and soybeans, by State and for the Unites States, 2000-13. http://www.ers.usda.gov/data-products/adoption-of-genetically-engineered-crops-in-the-us.aspx#.Ua58DGTb1bs

  24. Doerge D, Sheehan D.  Goitrogenic and Estrogenic Activity of Soy Isoflavones. Environmental Health Perspectives. v110 June 2002. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241182/pdf/ehp110s-000349.pdf

  25. Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75:145-153. http://ajcn.nutrition.org/content/75/1/145.abstract

  26. Asthma and Allergy Foundation of America. Peanut Allergy. Updated 2005 http://www.aafa.org/display.cfm?id=9&sub=20&cont=517

  27. Kritchevsky D, Tepper SA, Klurfeld DM. Lectin may contribute to the atherogenicity of peanut oil. Lipids. 1998;33:821–3. http://www.ncbi.nlm.nih.gov/pubmed/9727614

  28. Pramod SN, Venkatesh YP, Mahesh PA. Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E. Clin Exp Immunol. 2007;148:391–401.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941928/

  29. Singh R, Subramanian S, Rhodes JM, Campbell BJ. Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK: functional implications for disease-associated glycosylation changes. Glycobiology.2006;16:594–601 http://glycob.oxfordjournals.org/content/16/7/594.full

  30. Sategna-Guidetti C, Volta U, Ciacci C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. American Journal of Gastroenterology. 2001;96(3):751–757. http://www.ncbi.nlm.nih.gov/pubmed/11280546

  31. Brown A.C. Gluten Sensitivity, Problems of an Emerging Condition Separate From Celiac Disease Expert Rev Gastroenterol Hepatol. 2012;6(1):43-55.  http://www.ncbi.nlm.nih.gov/pubmed/22149581

  32. Tucková L, Tlaskalová-Hogenová H, Farré MA, et al. Molecular mimicry as a possible cause of autoimmune reactions in celiac disease? Antibodies to gliadin cross-react with epitopes on enterocytes. Department of Immunology and Gnotobiology, First Faculty of Medicine, Prague, Czech Republic. Clinical Immunology and Immunopathology [1995, 74(2):170-176  http://www1.lf1.cuni.cz/~kocna/docum/cs_tucko.pdf

  33. Miyake K, Tanaka T, McNeil PL. Lectin-Based Food Poisoning: A New Mechanism of Protein Toxicity. PLoS ONE (2007) 2(8): e687. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000687

  34. Fasano A. Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer. Physiol Rev. Vol 91. Jan 2011. 151175 http://www.ncbi.nlm.nih.gov/pubmed/21248165

  35. Fasano A. Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol. 2008;173:1243–1252.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570116/

  36. Arrieta MC, Bistritz L, Meddings JB, Alterations in intestinal permeability. Gut. 55: 1512–1520 (2006) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856434/pdf/1512.pdf

  37. Ulluwishewa D, Anderson RC, Mcnabb WC, Moughan PJ, Wells JM, Roy NC. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141:769–76 http://jn.nutrition.org/content/141/5/769.full

  38. Mishra A, Liu S, Sams G. H, et al.  Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation. Cancer Cell, 2012; 22 (5): 645 http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00394-7

  39. Baker S, Bennett P, Bland J. Textbook of functional medicine. Institute for Functional Medicine; Second edition (2005) Page 139

  40. Inadera H. The immune system as a target for environmental chemicals: xenoestrogens and other compounds. Toxicol Letters 2006;164: 191–206  http://www.ncbi.nlm.nih.gov/pubmed/16697129

  41. Ahmed SA, Hissong BD, Verthelyi D, Donner K, Becker K, Karpuzoglu-Sahin E. Gender and risk of autoimmune diseases: possible role of estrogenic compounds. Environ Health Perspect. 1999;107 (Suppl 5):681–686. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566250/

  42. Straub RH. 2007. The complex role of estrogens in inflammation. Endocr. Rev. 28: 521–574 http://edrv.endojournals.org/content/28/5/521.full

  43. Mayes M, Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives 11/1999; 107 Suppl 5:743-8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566245/pdf/envhper00522-0088.pdf

  44. Weidler C, Härle P, Schedel J, Schmidt M, Schölmerich J, Straub RH. Patients with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. J Rheumatol 31:489–494  2004  http://www.jrheum.org/content/31/3/489.short

  45. Vedhara K, Cox NK, Wilcock GK, et al. Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet. 1999 Feb 20;353(9153):627–31 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166443/

  46. Miller GE, Cohen S, Ritchey AK. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol 2002; 21: 531–541. http://www.ncbi.nlm.nih.gov/pubmed/12433005

  47. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A 71:1415–1429 2008. http://www.ncbi.nlm.nih.gov/pubmed/18800291

  48. Myers, RL and Myers, RL. The 100 most important chemical compounds: a reference guide. Westport, Conn: Greenwood Press. 2007.

  49. Mayo Clinic: Dept of Otorhinolaryngology. Research on Chronic Sinusitis. http://www.mayoclinic.org/ent-rst/chronicsinus.html

  50. Colborn T, Dumanoski D, Meyers J, Our Stolen Future: Are We Threatening Our Fertility, Intelligence, and Survival?–A Scientific Detective Story.  Plume (Mar. 1997) http://www.ourstolenfuture.org

  51. Department of Health and Human Services. Third National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: Centers for Disease Control and Prevention; July 2005.

  52. Yurino H, Ishikawa S, Sato T, Akadegawa K, Ito T, Ueha S, et al. Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells. Toxicol Sci. 2004;81:139–47 http://www.ncbi.nlm.nih.gov/pubmed/15166399

  53. Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, et al. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 2007; 24: 199–224. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151845/

  54. Ye X, Bishop AM, Reidy JA, Needham LL, Calafat AM. Parabens as urinary biomarkers of exposure in humans. Environ Health Perspect. 2006a;114:1843–1846. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764178/

  55. Menegaux F, Baruchel A, Bertrand Y, et al. Household exposure to pesticides and risk of childhood acute leukaemia. Occupational and Environmental Medicine. 2006;63(2):131–134. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2078075/

  56. Zhang Y, Guo GL, Han X, et al. Do polybrominated diphenyl ethers (PBDE) increase the risk of thyroid cancer? Bioscience Hypotheses. 2008;1(4):195–199 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612591/figure/F1/

  57. Zhang Y, Guo GL, Han X, et al. Do polybrominated diphenyl ethers (PBDE) increase the risk of thyroid cancer? Bioscience Hypotheses. 2008;1(4):195–199 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612591/

  58. Yi J, Cao J. Tea and fluorosis. Journal of Fluorine Chemistry 129:1976-81. (2008).

  59. Whitford G. Tea contains more fluoride than once thought. Georgia Health Sciences University. Jul. 2010 http://www.eurekalert.org/pub_releases/2010-07/mcog-tcm071410.php

  60. Diesendorf M. The mystery of declining tooth decay. Nature 1986 Jul 10;322:125- 9 http://www.nature.com/nature/journal/v322/n6075/pdf/322125a0.pdf

  61. Braathen M, Derocher AE, Wiig O, Sormo EG, Lie E, Skaare JU, Jenssen BM. Relationships between PCBs and thyroid hormones and retinol in female and male polar bears. Environ Health Perspect. 2004;112:826–833 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242008/

  62. Schiraldi M., Monestier M. How can a chemical element elicit complex immunopathology? Lessons from mercury-induced autoimmunity. (2009) Trends Immunol. 30, 502–509. http://toxcenter.org/artikel/Quecksilber-crasht-Autoimmunitaet.pdf

  63. Exley C, Begum A, Woolley MP, Bloor RN. Aluminum in tobacco and cannabis and smoking-related disease. Am. J. Med. 2006;119:276 e9–276  http://www.ncbi.nlm.nih.gov/pubmed/16490479

  64. Tomljenovic L. Aluminum and Alzheimer’s disease: after a century of controversy, is there a plausible link?  J Alzheimers Dis. 2011;23:567–598 http://www.ncbi.nlm.nih.gov/pubmed/21157018

  65. Sterzl I, Procházková J, Hrda P, Matucha P, Bartova J, Stejskal V. Removal of dental amalgam decreases anto-TPO and anti-Tg autoantibodies in patients with autoimmune thyroiditis. Neuro Endocrinol Lett. 2006;5(27(Suppl 1):25–30 http://www.ncbi.nlm.nih.gov/pubmed/16804512

  66. Geier D, Kern J, Garver C, et al. Biomarkers of environmental toxicity and susceptibility in autism, Journal of the Neurological Sciences, Volume 280, Issues 1–2, 15 May 2009, Pages 101-10 http://www.sciencedirect.com/science/article/pii/S0022510X08004310

  67. Shoenfeld Y, Agmon-Levin N. ‘ASIA’ – autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011;11:4–8 http://www.ncbi.nlm.nih.gov/pubmed/20708902?dopt=Abstract&holding=f1000,f1000m,isrctn

  68. Tomljenovic L, Shaw CA. Aluminum Vaccine Adjuvants: Are they Safe? Curr Med Chem. 2011;18:2630–2637  http://www.ncbi.nlm.nih.gov/pubmed/21568886

  69. Tomljenovic L, Shaw CA. Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations. Lupus February 2012 21: 223-230 http://lup.sagepub.com/content/21/2/223

  70. National Network for Immunization Information. Aluminum Adjuvants in Vaccines. Nov. 2008 http://www.immunizationinfo.org/issues/vaccine-components/aluminum-adjuvants-vaccines

  71. Cherry JD. Why do pertussis vaccines fail? Pediatrics 129: 968–970 (2012)

  72. Centers for Disease Control and Prevention. Interim Adjusted Estimates of Seasonal Influenza Vaccine Effectiveness — United States, February 2013  http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6207a2.htm?s_cid=mm6207a2_w

  73. Orenstein WA, Heseltine PN, LeGagnoux SJ, Portnoy B. Rubella vaccine and susceptible hospital employees. Poor physician participation. JAMA. 1981 Feb 20;245(7):711–713 http://www.ncbi.nlm.nih.gov/pubmed/7463660

Part Two

Chapter 12

  1. The American Academy of Clinical Endocrinologists www.aacc.org/SiteCollectionDocuments/NACB/LMPG/…/3c_thyroid.doc

  2. American Association of Clinical Endocrinologists. Over 13 Million Americans with Thyroid Disease Remain Undiagnosed. January 2003 Press Release. http://www.hospitalsoup.com/public/AACEPress_release-highlighted.pdf

Chapter 13

  1. Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T. Test for recovery from hypothyroidism during thyroxine therapy in Hashimoto’s thyroiditis. Lancet. 1990;336(8723):1084–6 http://www.ncbi.nlm.nih.gov/pubmed/1977978

  2. Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T. Test for recovery from hypothyroidism during thyroxine therapy in Hashimoto’s thyroiditis. Lancet. 1990;336(8723):1084–6 http://www.ncbi.nlm.nih.gov/pubmed/1977978

Chapter 14

  1. Intahphuak S, Khonsung P, Panthong A. Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharmaceutical Biology. 2010;48(2):151–157  http://www.ncbi.nlm.nih.gov/pubmed/20645831

  2. Takahashi M, Inoue S, Hayama K, Ninomiya K, Abe S. Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitoro and its therapeutic efficacy in murine oral candidiasis.  Med Mycol J. 2012;53(4):255-61.  http://www.ncbi.nlm.nih.gov/pubmed/23257726

  3. Reger MA, Henderson ST, Hale C. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004 Mar;25(3):311-4  http://www.ncbi.nlm.nih.gov/pubmed?term=Neurobiol%20Aging.%202004%20Mar;25(3):311-4

  4. St-Onge MP, Jones PJ.  Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity.  J Nutr. 2002 Mar;132(3):329-32.  http://www.ncbi.nlm.nih.gov/pubmed/11880549?dopt=Abstract

  5. Bergsson G, Arnfinnsson J, Ólafur Steingrı́msson, Thormar H. In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides. Antimicrob. Agents Chemother. November 2001 vol. 45 no. 11 3209-3212  http://aac.asm.org/content/45/11/3209.full

  6. Boyages S. Progress in Understanding the Clinical Consequences of Endemic Iodine Deficiency. Current Opinion in Endocrinology, Diabetes and Obesity 4.5 (1997): 320-327. http://www.researchgate.net/publication/232133920_Progress_in_understanding_the_clinical_consequences_of_endemic_iodine_deficiency

  7. Keck AS, Finley JW. Cruciferous Vegetables: Cancer Protective Mechanisms of Glucosinolate Hydrolysis Products and Selenium. Integr Cancer Ther March 2004 3: 5-12 http://www.ncbi.nlm.nih.gov/pubmed/15035868  –

  8. Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.  Biochimica et Biophysica Acta (BBA) – Molecular Cell Research. Oct 2012, Vol. 1823, No. 10: 1914-192 http://www.ncbi.nlm.nih.gov/pubmed/22820176

Chapter 15

  1. Kaushik RM, Kaushik R, Mahajan SK, Rajesh V. Effects of mental relaxation and slow breathing in essential hypertension. Complement Ther Med. 2006;14:120–6. http://www.complementarytherapiesinmedicine.com/article/S0965-2299(05)00148-2/fulltext

  2. National Sleep Foundation. Annual Sleep in America Poll Exploring Connections with Communications Technology Use and Sleep. Published Online. March 7, 2011. http://www.sleepfoundation.org/article/press-release/annual-sleep-america-poll-exploring-connections-communications-technology-use-

  3. National Sleep Foundation. How Much Sleep Do Adults Need? http://www.sleepfoundation.org/article/white-papers/how-much-sleep-do-adults-need

  4. Lashley FR. A review of sleep in selected immune and autoimmune disorders. Holist Nurs Pract. 2003 Mar-Apr;17(2):65-80. http://www.anapsid.org/cnd/files/sleep-in-selected-ai.pdf

  5. Yu X, Rollins D, Ruhn KA, et al. TH17 cell differentiation is regulated by the circadian clock. Science. 2013 Nov 8;342(6159):727-30. http://www.ncbi.nlm.nih.gov/pubmed/24202171

  6. Waite JC, Skokos D. Th17 Response and Inflammatory Autoimmune Diseases. Int J Inflam. 2012;2012:819467  http://www.ncbi.nlm.nih.gov/pubmed/22229105

  7. Nedergaard M, Xie L, Kang H, et al. Sleep Drives Metabolite Clearance from the Adult Brain. Science 18 October 2013: 342 (6156), 373-377. http://www.sciencemag.org/content/342/6156/373

  8. Roehrs T, Roth T. Sleep, sleepiness, sleep disorders and alcohol use and abuse. Sleep Medicine Reviews. 2001;5(4):287–297.  http://www.ncbi.nlm.nih.gov/pubmed/12530993

  9. Leggio L, Ray LA, Kenna GA, Swift RM. Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study. Alcoholism: Clinical and Experimental Research. 2009b;33:1539–1544.  http://www.ncbi.nlm.nih.gov/pubmed/19485973

  10. Mirrakhimov A, Mirrakhimov E M. Obstructive Sleep Apnea and Autoimmune Disease: A Two-Way Process. J Clin Sleep Med. 2013 April 15; 9(4): 409. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601322/

  11. Coughlin SR, Mawdsley L, Mugarza JA, Calverley PM, Wilding JP (2004) Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J 25: 735–741. http://www.ncbi.nlm.nih.gov/pubmed/15120883

  12. Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med. 2002;13(5):670–676. http://www.ncbi.nlm.nih.gov/pubmed/11874812

  13. Yu JC, Berger P 3rd. Sleep apnea and obesity. S D Med. 2011;Spec No:28-34. http://www.ncbi.nlm.nih.gov/pubmed/21717814

  14. Schwartz AR, Gold AR, Schubert N, et al. Effect of weight loss on upper airway collapsibility in obstructive sleep apnea. Am Rev Respir Dis. 1991;144(3 Pt 1):494–498. http://www.ncbi.nlm.nih.gov/pubmed/1892285

  15. Puhan M. A., Suarez A., Lo Cascio C., Zahn A., Heitz M., Braendli O. (2006). Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial. Br. Med. J. (Clin. Res. Ed.) 332, 266–270.10.1136/bmj.38705.470590.55  http://www.ncbi.nlm.nih.gov/pubmed/16377643

  16. Ryan RM, Weinstein N, Bernstein J, Brown KW, Mistretta L, Gagne´ M. Vitalizing effects of being outdoors and in nature. Journal of Environmental Psychology 30 (2010) 159–168.  http://www.researchgate.net/publication/228478393_Vitalizing_effects_of_being_outdoors_and_in_nature/file/32bfe513dd5917a305.pdf.

  17. Howell AJ, Dopko RL, Passmore HA, Buro K. Nature connectedness: Associations with well-being and mindfulness. Personality and Individual Differences Vol. 51, Issue 2, July 2011, Pages 166–171. http://www.sciencedirect.com/science/article/pii/S0191886911001711

  18. Berk LS, Tan SA, Fry WF, et al. Neuroendocrine and stress hormone changes during mirthful laughter. Am J Med Sci. 1989;298:390–6. http://www.ncbi.nlm.nih.gov/pubmed/2556917

  19. Hori M, Hayashi T, Nakagawa Y, Sakamoto S, Urayama O, Murakami K. Positive emotion-specific changes in the gene expression profile of tickled rats. Mol Med Rep. 2009 Mar-Apr;2(2):157-61. http://www.spandidos-publications.com/mmr/2/2/157

Chapter 16

  1. Prakash S, Rodes L, Coussa-Charley M, Tomaro-Duchesneau C (2011) Gut microbiota: next frontier in understanding human health and development of biotherapeutics. Biol Targ Ther 5: 71-86. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156250/

  2. Fasano A. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol. 2012;5:71–78.  http://www.ncbi.nlm.nih.gov/pubmed/22109896

  3. Andrès E, Noel E, Ben Abdelghani M. Vitamin B12 deficiency associated with chronic acid suppression therapy. Ann Pharmacother2003;37:1730  http://www.ncbi.nlm.nih.gov/pubmed/14565839

  4. Gardner MLG. Gastrointestinal absorption of intact proteins. Annu Rev Nutr. 1988;8:329–50. http://www.ncbi.nlm.nih.gov/pubmed/3060169

  5. Kwon H-K, Lee C-G, So J-S, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(5):2159–2164.  http://www.ncbi.nlm.nih.gov/pubmed/20080669

  6. Ghadimi D., Folster-Holst R., de Vrese M., Winkler P., Heller K.J., Schrezenmeir J. Effects of probiotic bacteria and their genomic DNA on TH1/TH2-cytokine production by peripheral blood mononuclear cells (PBMCs) of healthy and allergic subjects. Immunobiology. 2008;213:677–692.  http://www.ncbi.nlm.nih.gov/pubmed/18950596

  7. Hougee S, Vriesema AJM, Wijering SC, et al. Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study. International Archives of Allergy and Immunology. 2010;151(2):107–117.  http://www.ncbi.nlm.nih.gov/pubmed/19752564

  8. Rossi M, Amaretti A, Raimondi S. Folate production by probiotic bacteria. Nutrients 2011;3:118-34. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257725/

  9. Dan Lukaczar, ND. The “4” R Program. Textbook of functional medicine. Institute for Functional Medicine; Second edition (2010) Page 468.

  10. Souba WW, Klimberg VS, Plumley DA, Salloum RM, Flynn TC, Bland KI, Copeland EM 3rd. The role of glutamine in maintaining a healthy gut and supporting the metabolic response to injury and infection. J Surg Res. 1990 Apr;48(4):383-91.  http://www.ncbi.nlm.nih.gov/pubmed/2187115

  11. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK et al. (1997) L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am J Physiol 272: G943-G953.  http://www.ncbi.nlm.nih.gov/pubmed/9176200

  12. Cho C.H. Zinc: Absorption and Role in Gastrointestinal Metabolism and Disorders Dig Dis. 1991;9(1):49-60. http://www.ncbi.nlm.nih.gov/pubmed/2009637

  13. Semrad CE. Zinc, and intestinal function. Curr Gastroenterol Rep 1: 398–403, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10980978

  14. Wapnir R. Zinc Deficiency, Malnutrition and the Gastrointestinal Tract. J. Nutr. May 1, 2000 vol. 130 no. 5 1388S-1392S.  http://jn.nutrition.org/content/130/5/1388S.full

  15. Sturniolo GC, Leo DiV, Ferronato A, D’Odorico A, D’Inca R. Zinc supplementation tightens “leaky gut” in Crohn’s disease. Inflamm Bowel Dis. 2001;7:94–98.   http://www.ncbi.nlm.nih.gov/pubmed/11383597

  16. Centanni M, Gargano L, Canettieri G, et al. Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. N Engl J Med. 2006;354(17):1787–1795.  http://www.ncbi.nlm.nih.gov/pubmed/16641395

  17. Reimer C, Søndergaard B, Hilsted L, Bytzer P. Proton-Pump Inhibitor Therapy Induces Acid-Related Symptoms in Healthy Volunteers After Withdrawal of Therapy. Gastroenterology 1 July 2009 vol. 137 issue 1 Pages 80-87.  http://www.gastrojournal.org/article/S0016-5085(09)00522-8/fulltext

  18. Medical News Today Online. Gelatin Treats Ulcers. August 2006 http://www.medicalnewstoday.com/releases/50126.php

  19. Hering NA, Schulzke JD. Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig Dis. 2009;27:450–454. http://www.ncbi.nlm.nih.gov/pubmed/19897959

  20. Russell RI, Morgan RJ, Nelson LM. Studies on the protective effect of deglycyrrhinised liquorice against aspirin (ASA) and ASA plus bile acid-induced gastric mucosal damage, and ASA absorption in rats. Scand J Gastroenterol Suppl. 1984;92:97-100. http://www.ncbi.nlm.nih.gov/pubmed/6588541

  21. Naliboff B, Mayer M, Fass R, et al. The Effect of Stress on Symptoms of Heartburn. Psychosomatic Medicine May 1, 2004 vol. 66 no. 3 426-434 http://www.psychosomaticmedicine.org/content/66/3/426.full

  22. Bradley LA, Richter JE, Pulliam TJ, et al. The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors. Am J Gastroenterol 1993; 88:11-19. http://www.ncbi.nlm.nih.gov/pubmed/8420248

  23. Naliboff B, Mayer M, Fass R, et al. The Effect of Stress on Symptoms of Heartburn. Psychosomatic Medicine May 1, 2004 vol. 66 no. 3 426-434 http://www.psychosomaticmedicine.org/content/66/3/426.full

  24. Centanni M, Gargano L, Canettieri G, et al. Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. N Engl J Med. 2006;354(17):1787–1795.  http://www.ncbi.nlm.nih.gov/pubmed/16641395

  25. Yancy WS Jr, Provenzale D, Westman EC. Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: five brief case reports.  Altern Ther Health Med. 2001 Nov-Dec;7(6):120, 116-9.  http://www.ncbi.nlm.nih.gov/pubmed/11712463

  26. Austin GL, Thiny MT, Westman EC, Yancy WS Jr, Shaheen NJ. A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms.  Dig Dis Sci. 2006 Aug;51(8):1307-12. Epub 2006 Jul 27. http://www.ncbi.nlm.nih.gov/pubmed/16871438

Chapter 17

  1. Nomura S, Pittman CS, Chambers JB,  Buck MW, Shimizu T, Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis. J Clin Invest. 1975 September; 56(3): 643–652. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC301912/

  2. Richardson B. DNA methylation and autoimmune disease. Clin Immunol. 2003 Oct;109(1):72-9.  http://www.ncbi.nlm.nih.gov/pubmed/14585278

  3. Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 1990 Nov;33(11):1665-73. http://www.ncbi.nlm.nih.gov/pubmed/2242063

  4. Sekigawa I, Kawasaki M, Ogasawara H, et al. DNA methylation: its contribution to systemic lupus erythematosus. Clin Exp Med. 2006;6:99–106.  http://www.ncbi.nlm.nih.gov/pubmed/17061057

  5. Reprinted with permission from: Methylation: The Molecule That Unlocks The Body’s Healing Response; A Key To: Detoxification, Cell Repair, Graceful Aging, Weight Loss, Neurotransmitter Balance, Healthy Immunity, Disease Prevention, Nerve Protection, and so much more.  By Dr. Jack Tips, N.D., Ph.D.,  C.Hom., C.C.N. Published Online: http://www.anma.org/pdf/Methylation_by_Dr_Jack_Tips_Complete_and_Illustrated_Article.pdf

  6. Lim U, Song MA. Dietary and lifestyle factors of DNA methylation. Methods Mol Biol. 2012;863:359-76  http://www.ncbi.nlm.nih.gov/pubmed/22359306

  7. Tapp HS, Commane DM, Bradburn DM, et al. Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell. 2013 Feb;12(1):148-55. http://www.ncbi.nlm.nih.gov/pubmed/23157586

  8. Reprinted with permission from: Methylation: The Molecule That Unlocks The Body’s Healing Response; A Key To: Detoxification, Cell Repair, Graceful Aging, Weight Loss, Neurotransmitter Balance, Healthy Immunity, Disease Prevention, Nerve Protection, and so much more.  By Dr. Jack Tips, N.D., Ph.D.,  C.Hom., C.C.N. Published Online: http://www.anma.org/pdf/Methylation_by_Dr_Jack_Tips_Complete_and_Illustrated_Article.pdf

  9. Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. http://www.ncbi.nlm.nih.gov/pubmed/19393193

  10. Habdous M, Siest G, Herbeth B, Vincent-Viry M, Visvikis S. [Glutathione S-transferases genetic polymorphisms and human diseases: overview of epidemiological studies]. [Article in French] Ann Biol Clin (Paris). 2004 Jan-Feb;62(1):15-24. http://www.ncbi.nlm.nih.gov/pubmed/15047486

  11. Choi SW, Friso S. Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr November 2010 Adv Nutr vol. 1: 8-16, 2010. http://advances.nutrition.org/content/1/1/8.full

  12. Eckmekcioglu C, Strauss-Blasche G, Holzer F, Marktl W. Effect of sulfur baths on antioxidative defense systems, peroxide concentrations and lipid levels in patients with degenerative osteoarthritis. Forsch Komplementarmed Klass Naturheilkd. 2002;9:216–20.  http://www.ncbi.nlm.nih.gov/pubmed/12232493

  13. Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004 Jun;9(2):136-56. http://www.ncbi.nlm.nih.gov/pubmed/15253675

  14. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 Feb 9;179 (4073):588-90. http://www.ncbi.nlm.nih.gov/pubmed/4686466

  15. Johnston CS, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood cell glutathione in healthy adults. Am J Clin Nutr. 1993 Jul;58(1):103-5. http://ajcn.nutrition.org/content/58/1/103.full.pdf

  16. Jain SK, Micinski D. Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. Biochem Biophys Res Commun. 2013 Jul 19;437(1):7-11. http://www.ncbi.nlm.nih.gov/pubmed/23770363

  17. Kechrid Z, Hamdi M, Naziroğlu M, Flores-Arce M. Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet. Biol Trace Elem Res. 2012 Sep;148(3):371-7.  http://www.ncbi.nlm.nih.gov/pubmed/22410949

  18. Milad K, Racz O, Ipulova A, Bajova V, Kovae G. Effect of vitamin E and selenium on blood glutathione peroxidase activity and some immunological parameters in sheep. Vet. Med. – Czech., 46, 2001 (1): 1–5 http://vri.cz/docs/vetmed/46-1-1.pdf

  19. Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc. 1999 Jul;31(7):987-97. http://www.ncbi.nlm.nih.gov/pubmed/10416560

  20. Everson CA, Laatsch CD, Hogg N (2005) Antioxidant defense responses to sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol 288: R374-R383. http://ajpregu.physiology.org/content/288/2/R374.long

  21. Valenzuela, A.; Aspillaga, M.; Vial, S.; Guerra, R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med. 1989, 55, 420–422.  http://www.ncbi.nlm.nih.gov/pubmed/2813578

  22. Zheng S, Yumei F, Chen A.De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radic Biol Med. 2007 Aug 1;43(3):444-53. http://www.ncbi.nlm.nih.gov/pubmed/17602960

  23. Burgunder JM, Varriale A, Lauterburg BH (1989) Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol 36: 127–131. http://www.ncbi.nlm.nih.gov/pubmed/2721538

  24. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. http://www.ncbi.nlm.nih.gov/pubmed/19664690

  25. Vendemiale G, Altomare E, Trizio T, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989 May;24(4):407-15. http://www.ncbi.nlm.nih.gov/pubmed/2781235

  26. Heim  K. Glutathione bioavailability:_New technology confronts old questions. Published online 2013 Feb 27 http://www.pureencapsulations.com/education-research/newscaps/newscap-02-27-13

  27. 2004 Global Amphibian Assessment (GAA), http://www.iucnredlist.org/initiatives/amphibians/analysis

  28. Colson D G. A Safe Protocol for Amalgam Removal. J Environ Public Health. 2012; 2012: 517391. http://www.hindawi.com/journals/jeph/2012/517391/

  29. Environmental Protection Agency. Mercury: Laws and Regulations: http://www.epa.gov/hg/regs.htm

  30. Prochazkova J, Sterzl I, Kucerova H, Bartova J, Stejskal VD. The beneficial effect of amalgam replacement on health in patients with autoimmunity. NeuroendocrinologyLetters No.3 June Vol.25, 2004. http://www.nel.edu/pdf_/25_3/NEL250304A07_Prochazkova_.pdf

Chapter 18

  1. Cusick MF1, Libbey JE, Fujinami RS. Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol. 2012 Feb;42(1):102-11. http://www.ncbi.nlm.nih.gov/pubmed/22095454

  2. Oldstone MB. Molecular mimicry and immune-mediated diseases. FASEB J. 1998 Oct;12(13):1255-65.  http://www.ncbi.nlm.nih.gov/pubmed/9761770

  3. Fujinami RS, von Herrath MG, Christen U, Whitton JL. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev. 2006;19:80–94. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360274/

  4. Sfriso P, Ghirardello A, Botsios C, et al. Infections and autoimmunity: the multifaceted relationship. J Leukoc Biol. 2010 Mar;87(3):385-95. http://www.jleukbio.org/content/87/3/385.full.pdf

  5. Pancewicz SA, Skrzydlewska E, Hermanowska-Szpakowicz T, Zajkowska JM, Kondrusik M. Role of reactive oxygen species (ROS) in patients with erythema migrans, an early manifestation of Lyme borreliosis. Med Sci Monit. 2001;7:1230–1235. http://www.ncbi.nlm.nih.gov/pubmed/11687735

  6. Roederer M.; Raju P.A.; Staal F.J.T.; Herzenberg L.A.; Herzenberg L.A., 1991: N acetylcysteine inhibits latent hiv expression in chronically infected cells. Aids Research & Human Retroviruses. 7(6): 563-567.  http://eurekamag.com/research/007/581/n-acetylcysteine-inhibits-latent-hiv-expression-chronically-infested-cells.php

  7. Staal FJ, Roederer M, Israelski DM, Bubp J, Mole LA, et al. (1992) Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals. AIDS Res Hum Retroviruses 8: 305–311. http://www.ncbi.nlm.nih.gov/pubmed/1540417

  8. Ciriolo MR, Palamara AT, Incerpi S, et al. Loss of GSH, oxidative stress, and decrease of intracellular pH as sequential steps in viral infection. J. Biol. Chem. (1997); 272 (5): 2700-2708. http://www.jbc.org/content/272/5/2700.full

  9. Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP. Inhibition of influenza infection by glutathione. Free Radical Biology & Medicine (2003); 34 (7): 928-936. http://www.ncbi.nlm.nih.gov/pubmed/12654482

  10. Palamara AT, Perno CF, Ciriolo MR, Dini L, Balestra E, et al. (1995) Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication. Antiviral Res 27: 237–253. http://www.ncbi.nlm.nih.gov/pubmed/8540746

  11. Van Konynenburg, R.A. Glutathione Depletion—Methylation Cycle Block, A Hypothesis for the Pathogenesis of Chronic Fatigue Syndrome. Poster paper, 8th Intl. IACFS Conf. on CFS, Fibromyalgia, and Other Related Illnesses, Fort Lauderdale, FL, January 10-14, 2007.

http://phoenixrising.me/research-2/glutathione-depletionmethylation-blockades-in-chronic-fatigue-syndrome/glutathione-depletion-methylation-cycle-block-a-hypothesis-for-the-pathogenesis-of-chronic-fatigue-syndrome-by-richard-a-van-konynenbury-ph-d

  1. Taylor, E.W., Selenium and viral diseases: facts and hypotheses, J. Orthomolec. Med. (1997); 12 (4): 227-239. http://orthomolecular.org/library/jom/1997/pdf/1997-v12n04-p227.pdf

  2. Sfriso P, Ghirardello A, Botsios C, et al. Infections and autoimmunity: the multifaceted relationship. J Leukoc Biol. 2010 Mar;87(3):385-95. http://www.jleukbio.org/content/87/3/385.full.pdf

  3. Almas K, Al-Sanawi E, Al-Shahrani B. The effect of tongue scraper on mutans streptococci and lactobacilli in patients with caries and periodontal disease. Odontostomatol Trop. 2005;28:5–10. http://www.ncbi.nlm.nih.gov/pubmed/16032940

  4. Quirynen M, Avontroodt P, Soers C, Zhao H, Pauwels M, van Steenberghe D. Impact of tongue cleansers on microbial load and taste. J Clin Periodontol. 2004;3:506–10. http://www.ncbi.nlm.nih.gov/pubmed/15191584

  5. University At Buffalo. Researchers Show Chronic Sinusitis Is Immune Disorder; Antifungal Medicine Effective Treatment. ScienceDaily. www.sciencedaily.com/releases/2004/03/040324072619.htm (accessed March 2, 2014).

  6. Kern E, Sherris D, Ponikau J, et al. Diagnosis and treatment of chronic rhinosinusitis: focus on intranasal Amphotericin B. Ther Clin Risk Manag. Jun 2007; 3(2): 319–325. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936313/

  7. Choudhary TS, Mishra R, Choudhary A. Effect of yoga intervention in chronic rhinosinusitis. International Journal of Bioassays, [S.l.], v. 1, n. 12, p. 214-216, nov. 2012. ISSN 2278-778X. http://www.academia.edu/2515039/EFFECT_OF_YOGA_INTERVENTION_IN_CHRONIC_RHINOSINUSITIS

  8. Sengupta P. Health impacts of yoga and pranayama: A state-of-the-art review. Int J Prev Med. 2012;3:444–58. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415184/

  9. Ginde AA, Liu MC, Camargo CA., Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. 2009;169:626–32. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447083/

  10. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–2196. http://www.ncbi.nlm.nih.gov/pubmed/23245607

  11. Fisher JF, Kavanagh K, Sobel JD, Kauffman CA, Newman CA. Candida urinary tract infections—epidemiology, pathogenesis, diagnosis, and treatment: executive summary. Clinical Infectious Diseases. 2011;52(6):S429–S432. http://cid.oxfordjournals.org/content/52/suppl_6/S437.full

  12. Ledezma E, DeSousa L, Jorquera A, et al. Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis. Mycoses. 1996 Sep-Oct;39(9-10):393-5.

http://www.ncbi.nlm.nih.gov/pubmed/9009665

  1. Cvetnić Z, Vladimir-Knezević S. Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Acta Pharm 54.3 (2004): 243-250. http://www.ncbi.nlm.nih.gov/pubmed/15610620

  2. Omar SH. Oleuropein in olive and its pharmacological effects. Scientia Pharmaceutica. 2010;13:133–154. http://www.ncbi.nlm.nih.gov/pubmed/21179340

  3. Sudjana AN, D’Orazio C, Ryan V, Rasool N, Ng J, Islam N, et al. Antimicrobial activity of commercial Olea europaea (olive) leaf extract. Int J Antimicrob Agents. 2009;33:461–3. http://www.ncbi.nlm.nih.gov/pubmed/19135874

  4. Bao J, Zhang DW, Zhang JZH, Huang PL, Huang PL, Lee-Huang S. Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41. FEBS Lett. 2007;581:2737–2742. http://www.ncbi.nlm.nih.gov/pubmed/17537437

  5. Mahmoud DA. Hassanein NM. Youssef KA. Abou Zeid MA. Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens. Braz. J. Microbiol. vol.42 no.3 São Paulo July/Sept. 2011 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300021

  6. Mohanty SS, Raghavendra K, Dash AP. Influence of growth medium on antifungal activity of neem oil (Azadirachta indica) against Lagenidium giganteum and Metarhizium anisopliae.

Mycoscience (Impact Factor: 1.17). 01/2008; 49(5):318-320. http://www.sciencedirect.com/science/article/pii/S1340354008702742

  1. Bounous G, Gold P. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med 1991;14:296–309. http://www.ncbi.nlm.nih.gov/pubmed/1782728

Chapter 19

  1. Babich, H, Babich, JP.  Sodium lauryl sulfate and triclosan: in vitro cytotoxicity studies with gingival cells. Toxicology Letters, Volume 91, issue 3 (May 16, 1997), p. 189-196.  http://www.ncbi.nlm.nih.gov/pubmed/9217239

  2. Lee CH, Kim HW, Han HJ,  Park CW.  A Comparison Study of Nonanoic Acid and Sodium Lauryl Sulfate in Skin Irritation.  Exog Dermatol 2004;3:19–25.  http://www.karger.com/Article/FullText/84139

  3. Mercola J. Deadly and Dangerous Shampoos, Toothpastes, and Detergents: Could 16,000 Studies Be Wrong About SLS?  July 13 2013 http://articles.mercola.com/sites/articles/archive/2010/07/13/sodium-lauryl-sulfate.aspx

  4. Donn J, Mendoza M, Pritchard J, PHARMAWATER I Pharmaceuticals found in drinking water, affecting wildlife and maybe humans. Associated Press. http://hosted.ap.org/specials/interactives/pharmawater_site/index.html

  5. Al-Saleh I, Shinwari N, Alsabbaheen A. Phthalates residues in plastic bottled waters. J Toxicol Sci. 2011;21:469–478.  http://www.ncbi.nlm.nih.gov/pubmed/21804311

  6. Zock JP, Plana E, Jarvis D, Antó JM, et al. The use of household cleaning sprays and adult asthma: an international longitudinal study. Am J Respir Crit Care Med. 2007;176:735–741. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020829/?tool=pubmed

  7. AromaWeb. Aromatherapy Diffusers. http://www.aromaweb.com/articles/diffu.asp

  8. Anne C. Steinemann, Lisa G. Gallagher, Amy L. Davis, Ian C. MacGregor. Chemical emissions from residential dryer vents during use of fragranced laundry products. Air Quality, Atmosphere & Health. March 2013, Volume 6, Issue 1, pp 151-156 http://link.springer.com/content/pdf/10.1007%2Fs11869-011-0156-1.pdf

  9. The Honest Company. Hypoallergenic & Natural Dryer Sheets. https://www.honest.com/cleaning/honest-dryer-cloths

  10. Zhu K, Hunter S, Payne-Wilks K, Roland CL, Forbes DS (2003) Use of Electric Bedding Devices and Risk of Breast Cancer in African-American Women. American Journal of Epidemiology 158: 798–806. http://www.ncbi.nlm.nih.gov/pubmed/14561670

  11. IARC Classifies Radiofrequency Electromagnetic Fields As Possibly Carcinogenic to Humans. WHO/International Agency for Research on Cancer (IARC) Press Release N° 208 May 31, 2011http://www.iarc.fr/en/media-centre/pr/2011/pdfs/pr208_E.pdf

  12. Mandalà M, Colletti V, Sacchetto L, Manganotti P, et al. Effect of Bluetooth headset and mobile phone electromagnetic fields on the human auditory nerve. Laryngoscope. 2013 Apr 25.

  13. Environmental Protection Agency. Home Buyer’s and Seller’s Guide to Radon. EPA 402/K-09/002 | January 2009 http://www.epa.gov/radon/pubs/hmbyguid.html

  14. Environmental Protection Agency. A Brief Guide to Mold, Moisture, and Your Home. EPA 402-K-02-003 (Reprinted 09/2010)  http://www.epa.gov/iedmold1/moldbasics.html

  15. Gray MR, Thrasher JD, Crago R, et al. Mixed mold mycotoxicosis: immunological changes in humans following exposure in water-damaged buildings. Archives of Environmental Health. 2004;58(7):410–420.  http://www.ncbi.nlm.nih.gov/pubmed/15143854

  16. Andersson MA, Nikulin M, Koljalg U, et al. Bacteria, molds, and toxins in water-damaged building materials. Appl Environ Microbiol 1997;63:387–393.  http://www.ncbi.nlm.nih.gov/pubmed/9023919

  17. Kuhn DM, Ghannoum MA. Indoor Mold, Toxigenic Fungi, and Stachybotrys chartarum: Infectious Disease Perspective. Clin Microbiol Rev. 2003 January; 16(1): 144–172.  http://cmr.asm.org/content/16/1/144.full

  18. The California Department of Public Health.  Occupational Health Hazard Alert Methylene Chloride in Paint Strippers and Bathtub Refinishing. http://www.cdph.ca.gov/programs/hesis/Documents/MethyleneChlorideAlert.pdf

  19. Urbansky E.T., Brown S.K., Magnuson M.L., Kelty C.A. Perchlorate levels in samples of sodium nitrate fertilizer derived from Chilean caliche. Environmental Pollution 112 (2001) 299±302 http://www.tera.org/ART/Perchlorate/EPClO4.pdf

  20. Centers for Disease Control and Prevention. National Center for Environmental Health. Perchlorate Fact Sheet October 5, 2006.  http://www.cdc.gov/nceh/publications/factsheets/perchlorate.htm

  21. Medline Plus, National Institutes of Health. Magnesium. Page last updated: 13 September 2013 http://www.nlm.nih.gov/medlineplus/druginfo/natural/998.html

  22. Nimni ME. Han B. Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond) 2007;4:24. http://www.nutritionandmetabolism.com/content/4/1/24

  23. Eckmekcioglu C, Strauss-Blasche G, Holzer F, Marktl W. Effect of sulfur baths on antioxidative defense systems, peroxide concentrations and lipid levels in patients with degenerative osteoarthritis. Forsch Komplementarmed Klass Naturheilkd. 2002;9:216–20.  http://www.ncbi.nlm.nih.gov/pubmed/12232493

  24. 2004 Global Amphibian Assessment (GAA), http://www.iucnredlist.org/initiatives/amphibians/analysis

Part Three

  1. Viljoen M, Panzer A, Roos J.L, Bodemer W. Psychoneuroimmunology: From Philosophy, Intuition and Folklore to a Recognized Science. South African Journal of Science 99 July/August 2003: 332. http://connection.ebscohost.com/c/articles/11532011/psychoneuroimmunology-from-philosophy-intuition-folklore-recognized-science

  2. Viljoen M, Panzer A, Roos J.L, Bodemer W. Psychoneuroimmunology: From Philosophy, Intuition and Folklore to a Recognized Science. South African Journal of Science 99 July/August 2003: 332. http://connection.ebscohost.com/c/articles/11532011/psychoneuroimmunology-from-philosophy-intuition-folklore-recognized-science

  3. Felitti V, Anda F, Nordenberg D,et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine – May 1998 ;Vol. 14, Issue 4, p 245-258 http://www.acestudy.org

  4. Kiecolt-Glaser J.K., McGuire L., Robles T.F., Glaser R. (2002) Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology. Annual Review Psycholgy 53, 83-107. http://www.ncbi.nlm.nih.gov/pubmed/11752480

  5. Barak Y. The immune system and happiness. Autoimmun Rev. 2006;5:523–527. http://www.ncbi.nlm.nih.gov/pubmed/17027886

  6. O’Connor M‐F, Irwin MR, Wellisch DK. When grief heats up: pro‐inflammatory cytokines predict regional brain activation. Neuroimage. 2009; 47:891-896

  7. Mayo Clinic. Complicated Grief. Sept. 29, 2011. http://www.mayoclinic.com/health/complicated-grief/DS01023

  8. Dickerson SS, Kemeny ME, Aziz N, Kim KH, Fahey JL. Immunological Effects of Induced Shame and Guilt. Psychosom Med. 2004 Jan-Feb;66(1):124-31.  http://www.ncbi.nlm.nih.gov/pubmed/14747646

  9. Lawler K. A., Younger J. W., Piferi R. L., Jobe R. L., Edmondson K. A., Jones W. H. (2005). The unique effects of forgiveness on health: an exploration of pathways. J.Behav. Med. 28, 157–167. http://www.ncbi.nlm.nih.gov/pubmed/15957571

  10. Lawler K. A., Younger J. W., Piferi R. L., Jobe R. L., Edmondson K. A., Jones W. H. (2005). The unique effects of forgiveness on health: an exploration of pathways. J.Behav. Med. 28, 157–167. http://www.ncbi.nlm.nih.gov/pubmed/15957571

Site by Yakadanda